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Invitrogen™ PRL3 Polyclonal Antibody
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Catalog No. PIPA5106905
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100 μL
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PIPA5106905 100 μL
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Catalog No. PIPA5106905 Supplier Invitrogen™ Supplier No. PA5106905
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PTP4A3.

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist. PRL-3 expression was found to be up-regulated in human liver carcinoma compared with normal liver. Its expression in colorectal cancers may contribute to the establishment of liver metastasis. In a different study, PRL-3 is found to be expressed in tumor metastasis and vasculature, regardless of the tumor source.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PRL3
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Ptp4a3
Gene Accession No. O75365, Q9D658
Gene Alias AV088979; HPRL-3; potentially prenylated protein tyrosine phosphatase; pPtp4a3; PRL3; Prl-3; PRL-R; protein tyrosine phosphatase 4a3; protein tyrosine phosphatase type IVA 3; protein tyrosine phosphatase type IVA, member 3; protein-tyrosine phosphatase 4a3; Protein-tyrosine phosphatase of regenerating liver 3; Ptp4a3
Gene Symbols Ptp4a3
Host Species Rabbit
Immunogen A synthesized peptide derived from human PTP4A3(Accession O75365), corresponding to amino acid residues R137-M173.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11156, 19245, 362930
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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