Invitrogen™ PRMT5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590290

Catalog No. PIPA590290

Description

Positive Samples: Jurkat, HepG2, HeLa, NIH/3T3, PC-12, COS-1; Cellular Location: Cytoplasm, Golgi apparatus, Nucleus Immunogen sequence: MAAMAVGGAG GSRVSSGRDL NCVPEIADTL GAVAKQGFDF LCMPVFHPRF KREFIQEPAK NRPGPQTRSD LLLSGRDWNT LIVGKLSPWI RPDSKVEKIR RNSEAAMLQE LNFGAYLGLP AFLLPLNQED NTNLARVLTN HIHTGHHSSM FWMRVPLVAP EDLRDDIIEN APTTHTEEYS GEEKTWMWWH NFRTLCDYSK RIAVALEIGA DLPSNHVIDR WLGEPIKAAI LPTSIFLTNK KGFPVLSKMH.

PRMT5 (protein arginine N-methyltransferase 5) is an arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. PRMT5 specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 and Sm D3; such methylation is required for the assembly and biogenesis of snRNP core particles.

Specifications

• Antigen: PRMT5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRMT5
• Gene Alias: 72 kDa ICln-binding protein; EC 2.1.1.125; histone-arginine N-methyltransferase PRMT5; HMT1 hnRNP methyltransferase-like 5; HRMT1L5; hypothetical protein; I79_013398; IBP72; Jak-binding protein 1; JBP1; PRMT5; protein arginine methyltransferase 5; protein arginine N-methyltransferase 5; Protein arginine N-methyltransferase 5, N-terminally processed; protein arginine N-methyltransferase 5-like; shk1 kinase-binding protein 1 homolog; Skb1; SKB1 homolog; SKB1Hs
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10419, 27374, 364382
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O14744, Q8CIG8
• Gene Symbols: PRMT5
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human PRMT5 (NP_0061002).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Rat
• Product Type: Antibody
• Isotype: IgG