Invitrogen™ PRMT6 Recombinant Rabbit Monoclonal Antibody (1Z10L6)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542871

Catalog No. PIMA542871

Description

Positive test controls include: HeLa, MCF7, NIH/3T3, Jurkat, Rat testis. The target is usually found in the following locations: Nucleus. Immunogen sequence: MLEWRLGFWS QVKQHYGVDM SCLEGFATRC LMGHSEIVVQ GLSGEDVLAR PQRFAQLELS RAGLEQELEA GVGGRFRCSC YGSAPMHGFA IWFQVTFPGG E.

Protein arginine N-methyltransferase 6 (PRMT6) PRMT6 demonstrates type I PRMT activity, capable of forming both omega-N monomethylarginine and asymmetric dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. cts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7.

Specifications

• Antigen: PRMT6
• Classification: Recombinant Monoclonal
• Concentration: 1.34 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q6NZB1, Q96LA8
• Gene Symbols: PRMT6
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PRMT6 (Q96LA8).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 1Z10L6
• Conjugate: Unconjugated
• Gene: PRMT6
• Gene Alias: AW124876; BB233495; FLJ10559; FLJ51477; heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6; HMT1 hnRNP methyltransferase-like 6; Hrmt1l6; PRMT6; PRMT-6; protein arginine methyltransferase 6; protein arginine N-methyltransferase 6
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 295384, 55170, 99890
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid