Invitrogen™ PRMT6 Recombinant Rabbit Monoclonal Antibody (8H9L19)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ 703547

Catalog No. 70-354-7

Description

This antibody is predicted to react with Monkey, Pig, Rat, Cat. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Protein arginine N-methyltransferase 6 (PRMT6) PRMT6 demonstrates type I PRMT activity, capable of forming both omega-N monomethylarginine and asymmetric dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. cts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. May play a role in innate immunity against HIV-1 in case of infection by methylating and impairing the function of various HIV-1 proteins such as Tat, Rev and Nucleocapsid protein p7.

Specifications

• Antigen: PRMT6
• Classification: Recombinant Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q96LA8
• Gene Symbols: PRMT6
• Immunogen: Peptides corresponding to human PRMT6 [1) aa37-aa49 2) aa358-aa375].
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: ChIP Assay, Immunocytochemistry, Immunofluorescence
• Clone: 8H9L19
• Conjugate: Unconjugated
• Gene: PRMT6
• Gene Alias: AW124876; BB233495; FLJ10559; FLJ51477; heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6; HMT1 hnRNP methyltransferase-like 6; Hrmt1l6; PRMT6; PRMT-6; protein arginine methyltransferase 6; protein arginine N-methyltransferase 6
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 55170
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

Safety and Handling

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