Invitrogen™ pro-Brain Natriuretic Peptide Monoclonal Antibody (5B6)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA120622

Catalog No. PIMA120622

Description

MA1-20622 detects proBNP in human samples.

In cardiac tissue brain natriuretic peptide (BNP) is synthesized as 134 amino acid precursor (prepro-BNP), which is cleaved by proteases to form a 26 aa 'signal' peptide and a 108 aa pro-BNP. Proteolytic digestion of pro-BNP results in formation of 76 aa amino-terminal NT-proBNP and biologically active 32 aa BNP hormone molecule. Both proBNP and NTproBNP circulate in human plasma and have been proposed as markers for early diagnosis of left ventricular dysfunction as well as prognostic markers of possible cardiac complications at patients with heart failure.

Specifications

• Antigen: pro-Brain Natriuretic Peptide
• Classification: Monoclonal
• Concentration: 5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: P16860
• Gene Symbols: NPPB
• Immunogen: Synthetic N-terminal pro brain natriuretic peptide (NT-proBNP), corresponding to amino acid residues 1-12. The peptides used for immunization were conjugated with carrier protein.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Western Blot
• Clone: 5B6
• Conjugate: Unconjugated
• Gene: NPPB
• Gene Alias: 5 kDa cardiac natriuretic peptide; AA408272; BNF; BNP; BNP(1-28); BNP(1-29); BNP(1-30); BNP(1-32); BNP(2-31); BNP(3-29); BNP(3-30); BNP(3-32); BNP(4-27); BNP(4-29); BNP(4-30); BNP(4-31); BNP(4-32); BNP(5-29); BNP(5-31); BNP(5-32); BNP32; BNP-34; Brain natriuretic factor; brain natriuretic peptide; Brain natriuretic peptide 32; Brain natriuretic peptide 45; brain type natriuretic peptide; gamma-brain natriuretic peptide; Iso-ANP; natriuretic peptide B; natriuretic peptide precursor B; natriuretic peptide precursor type B; natriuretic peptide type B; natriuretic peptides B; natriuretic protein; Nppb; NTproBNP; pro-BNP; type-B natriuretic factor
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 4879
• Content And Storage: 4°C
• Form: Liquid