Progesterone Receptor Monoclonal Antibody (hPRa 6), Invitrogen™

Catalog No.	Quantity
PIMA512653	500 μL

Catalog No. PIMA512653 Supplier Thermo Scientific Supplier No. MA512653

Description

Mouse Monoclonal Antibody

MA5-12653 targets Progesterone Receptor in IF and IP applications and shows reactivity with Bovine, Chicken, Human, and Rabbit samples. The MA5-12653 immunogen is partially purified PgR from a human endometrial carcinoma (EnCa 101) grown in athymic mice.

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.

Specifications

• Antigen: Progesterone Receptor
• Applications: Immunocytochemistry, Immunoprecipitation
• Classification: Monoclonal
• Clone: hPRa 6
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene: PGR
• Gene Accession No.: P06186, P06401, P07812
• Gene Alias: 9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product
• Gene Symbols: PGR
• Host Species: Mouse
• Immunogen: Partially purified PgR from a human endometrial carcinoma (EnCa 101) grown in athymic mice
• Purification Method: Protein A
• Quantity: 500 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100009094, 100848466, 396198, 5241
• Target Species: Bovine, Chicken, Human, Rabbit
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b