Invitrogen™ Prohibitin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587348

Catalog No. PIPA587348

Description

Positive Samples: Raji, NIH/3T3, HeLa, MCF7, HepG2, Mouse liver, Mouse heart, Mouse kidney, Rat heart; Cellular Location: Mitochondrion inner membrane Immunogen sequence: PRNVPVITGS KDLQNVNITL RILFRPVASQ LPRIFTSIGE DYDERVLPSI TTEILKSVVA RFDAGELITQ RELVSRQVSD DLTERAATFG LILDDVSLTH LTFGKEFTEA VEAKQVAQQE AERARFVVEK AEQQKKAAII SAEGDSKAAE LIANSLATAG DGLIELRKLE AAEDIAYQLS RSRNITYLPA GQSVLLQLPQ.

Prohibitin is from an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA.

Specifications

• Antigen: Prohibitin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PHB
• Gene Alias: BAP 32; Bap32; B-cell receptor-associated protein 32; epididymis luminal protein 215; epididymis secretory sperm binding protein Li 54e; fa18f07; fb09f05; HEL-215; HEL-S-54e; OTTHUMP00000165765; OTTHUMP00000165766; OTTHUMP00000220103; OTTHUMP00000220170; OTTHUMP00000220171; PHB; phb protein; PHB1; Prohibitin; sr:nyz128; wu:fa18f07; wu:fb09f05
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18673, 25344, 5245
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.36 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P35232, P67778, P67779
• Gene Symbols: PHB
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 73-272 of human Prohibitin (NP_0026251).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG