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Invitrogen™ Prolactin Receptor (ECD) Polyclonal Antibody
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Catalog No. PIPA5112169
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100 μL
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PIPA5112169 100 μL
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Catalog No. PIPA5112169 Supplier Invitrogen™ Supplier No. PA5112169
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Description

Rabbit Polyclonal Antibody

Prolactin Receptor (ECD) Polyclonal Antibody for Western Blot, IP

Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen Prolactin Receptor (ECD)
Applications Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.03% ProClin 300; pH 7
Gene ECD
Gene Accession No. O95905
Gene Alias 5730461K03Rik; Ecd; ecdysoneless cell cycle regulator; ecdysoneless homolog; ecdysoneless homolog (Drosophila); GCR2; HSGT1; Human suppressor of GCR two; protein ecdysoneless homolog; protein SGT1; protein SGT1 homolog; SGT1; SGT1 protein; suppressor of GCR2; suppressor of S. cerevisiae gcr2
Gene Symbols ECD
Host Species Rabbit
Immunogen E. coli-derived Human ECD fragment.
Purification Method Antigen Affinity Chromatography, Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11319
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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