Invitrogen™ Prolactin Receptor (ECD) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5112169

Catalog No. PIPA5112169

Description

Prolactin Receptor (ECD) Polyclonal Antibody for Western Blot, IP

Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). [UniProt].

Specifications

• Antigen: Prolactin Receptor (ECD)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ECD
• Gene Alias: 5730461K03Rik; Ecd; ecdysoneless cell cycle regulator; ecdysoneless homolog; ecdysoneless homolog (Drosophila); GCR2; HSGT1; Human suppressor of GCR two; protein ecdysoneless homolog; protein SGT1; protein SGT1 homolog; SGT1; SGT1 protein; suppressor of GCR2; suppressor of S. cerevisiae gcr2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 11319
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.03% ProClin 300; pH 7
• Gene Accession No.: O95905
• Gene Symbols: ECD
• Immunogen: E. coli-derived Human ECD fragment.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov