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Proprotein Convertase 2 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981452
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50-198-1452 100 μL
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Catalog No. 50-198-1452 Supplier Bioss Supplier No. BS11533R
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Rabbit Polyclonal Antibody

The subtilisin-like prohormone convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous approximately 10 kDa amino-terminal proregion, a highly conserved approximately 55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.

Specifications

Antigen Proprotein Convertase 2
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Pcsk2
Gene Accession No. P16519
Gene Alias 6330411F23Rik; AI839700; BOS_12928; EC 3.4.21.94; KEX2-like endoprotease 2; NEC 2; Nec2; Nec-2; Neuroendocrine convertase 2; PC2; Pcsk2; Phpp-2; Prohormone convertase 2; Proprotein convertase 2; proprotein convertase subtilisin/kexin type 2; proprotein convertase type 2; Rpc2; SPC2
Gene Symbols Pcsk2
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Proprotein Convertase 2.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5126
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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