Invitrogen™ Prosapip1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556614

Catalog No. PIPA556614

Description

Immunogen sequence: QEFAMKSVGT RTGGGGSQGS FPGPRGSGSG ASRERPGRYP SEDKGLANSL YLNGELRGSD HTDVCGNVVG SSGGSSSSGG SDKAPPQYRE PS Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 91%.

Prosapip1 is a binding partner of the postsynaptic density (PSD) protein ProSAP2/Shank3, a major scaffolding protein in excitatory brain synapses. Prosapip1 is thought to bind ProSAP2/Shank3 through a PDZ domain in ProSAP2/Shank3 and link it in turn to the Spine-associated Rap-Gap (SPAR). Prosapip1 shares significant homology with another PSD protein, PSD-Zip70, with both coding for a Fez1 domain that can be found in a total of four related protein, forming a novel family of scaffolding molecules termed 'Fezzins'. Recent studies show that Prosapip1 can be found in endocrine cells in which it is localized primarily in the hormone-storing compartment of these cells, suggesting that Prosapip1 may have other functions in non-neuronal cells.

Specifications

• Antigen: Prosapip1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Lzts3
• Gene Alias: KIAA0552; Leucine zipper putative tumor suppressor 3; leucine zipper tumor suppressor family member 3; leucine zipper, putative tumor suppressor family member 3; LZTS3; proline rich synapse associated protein interacting protein 1; proline rich synapse associated protein interacting protein 1 (Prosapip1); ProSAP/Shank-interacting protein 1; proSAP-interacting protein 1; PROSAPIP1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9762
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O60299
• Gene Symbols: Lzts3
• Immunogen: Recombinant protein corresponding to Human LZTS3. Recombinant protein control fragment (Product #RP-95501).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG