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Invitrogen™ Prosapip2 Polyclonal Antibody
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Catalog No. PIPA584674
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100 μL
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PIPA584674 100 μL
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Catalog No. PIPA584674 Supplier Invitrogen™ Supplier No. PA584674
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: ELKQLQETRA QDLASNQSER DMAWVKRVGD DQVNLALAYT ELTEELGRLR ELSSLQGRIL RTLLQEQARS G Highest antigen sequence indentity to the following orthologs: Mouse - 96%, Rat - 94%.

Prosapip2 (TBKBP1) is essential for signal transduction during viral infection thus plays a major role in the TNF/NF-kappa-B pathway. It is an adaptor protein that constitutively binds TBK1 (TANK-binding kinase) and IKBKE and may play a role in antiviral innate immunity. Prosapip2 is a 615 amino acid adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It has a ubiquitous expression with highest levels in ovary, followed by the neuronal system. Prosapip2 binds to TBK1 and helps in the activation of IRF3 which controls the expression of antiviral genes during infection. Recent studies show that Prosapip2 is an interaction partner of ProSAP2/Shank3 and actin, suggesting a role as a linker molecule between postsynaptic density and the cytoskeleton.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Prosapip2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TBKBP1
Gene Accession No. A7MCY6
Gene Alias 3110043L15Rik; KIAA0775; Prosapip2; Protein ProSAPiP2; RGD:631328}; Similar to NAP1 TBK1 adapter; Sintbad; TANK-binding kinase 1-binding protein 1; TBK1 binding protein 1; TBK1-binding protein 1; Tbkbp1; tbkbp1 {ECO:0000312
Gene Symbols TBKBP1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TBKBP1. Recombinant protein control fragment (Product #RP-103575).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9755
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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