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Invitrogen™ Protein APC Monoclonal Antibody (FE9)
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Catalog No. MA191039
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50 μg
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Catalog No. Quantity
MA191039 50 μg
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Catalog No. MA191039 Supplier Invitrogen™ Supplier No. MA191039
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Description

Mouse Monoclonal Antibody

Reacts with all full length and truncated APC proteins. MA1-91039 has been successfully used in Western blot applications, where a band of approximately 312 kDa is predicted to be detected. Suggested positive controls for this product are HCT116 cells for p300 and SW480 cells for truncated APC (p147).

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Protein APC
Applications Western Blot
Classification Monoclonal
Clone FE9
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation 0.05M sodium phosphate with 0.2% gelatin and 0.1% sodium azide; pH 7.5
Gene Apc
Gene Accession No. P25054, P70478, Q61315
Gene Alias adenomatosis polyposis coli; adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli; adenomatous polyposis coli protein; AI047805; APC; APC, WNT signaling pathway regulator; AU020952; AW124434; BTPS2; CC1; Deleted in polyposis 2.5; DP2; DP2.5; DP3; FAP; FPC; GS; mAPC; Min; multiple intestinal neoplasia; PPP1R46; Protein APC; protein phosphatase 1, regulatory subunit 46; RATAPC; truncated adenomatosis polyposis coli; WNT signaling pathway regulator
Gene Symbols Apc
Host Species Mouse
Immunogen Immunogen used was a synthetic peptide corresponding to the N-terminal 35 amino acid residues of APC.
Purification Method Protein G
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11789, 24205, 324
Target Species Human, Mouse, Rat
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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