Invitrogen™ Protein APC Monoclonal Antibody (KT44)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA547696

Catalog No. PIMA547696

Description

This antibody detects full length APC at 300 kDa* and proteolytic fragments of APC at lower molecular weights. The antibody detects APC or its fragments in SW480, CaCO2, DLD-1, and Hct116 cells. In immunocytochemistry, the antibody detects in APC in clusters at the plasma membrane and at the ends of microtubules.

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

Specifications

• Antigen: Protein APC
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: P25054, P70478, Q61315
• Gene Symbols: Apc
• Immunogen: Clone KT44 was generated from a recombinant protein containing amino acid residues from the central region mouse APC. This sequence is highly conserved in human and rat APC, and has low homology to APC2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Western Blot, Immunocytochemistry
• Clone: KT44
• Conjugate: Unconjugated
• Gene: Apc
• Gene Alias: adenomatosis polyposis coli; adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli; adenomatous polyposis coli protein; AI047805; APC; APC, WNT signaling pathway regulator; AU020952; AW124434; BTPS2; CC1; Deleted in polyposis 2.5; DP2; DP2.5; DP3; FAP; FPC; GS; mAPC; Min; multiple intestinal neoplasia; PPP1R46; Protein APC; protein phosphatase 1, regulatory subunit 46; RATAPC; truncated adenomatosis polyposis coli; WNT signaling pathway regulator
• Host Species: Rat
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 11789, 24205, 324
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid