Invitrogen™ Protein C Recombinant Rabbit Monoclonal Antibody (3W3R7)

Catalog No.	Quantity
PIMA535528	100 μL

Catalog No. PIMA535528 Supplier Invitrogen™ Supplier No. MA535528

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: IALLHLAQPA TLSQTIVPIC LPDSGLAERE LNQAGQETLV TGWGYHSSRE KEAKRNRTFV LNFIKIPVVP HNECSEVMSN MVSENMLCAG ILGDRQDACE GDSGGPMVAS FHGTWFLVGL VSWGEGCGLL HNYGVYTKVS RYLDWIHGHI RDKEAPQKSW AP.

Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3 ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3 μg/mL. Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

Specifications

• Antigen: Protein C
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: 3W3R7
• Concentration: 2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: PROC
• Gene Accession No.: P04070, P31394, P33587
• Gene Alias: Activation peptide; Anticoagulant protein C; APC; autoprothrombin IIA; Blood coagulation factor XIV; EDQVDPRLIDGK; inactivator of coagulation factors Va, VIII; PC; prepro-protein C; Proc; PROC1; protein C; protein C (inactivator of coagulation factors Va and VIIIa); protein C prepropeptide; protein C, inactivator of coagulation factors Va and VIIIa; THPH3; THPH4; type I protein C; vitamin K-dependent protein C; Vitamin K-dependent protein C heavy chain; Vitamin K-dependent protein C light chain
• Gene Symbols: PROC
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 300-461 of human Coagulation Protein C (P04070).
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19123, 25268, 5624
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG