Invitrogen™ Protein Tyrosine Phosphatase Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5112868

Catalog No. PIPA5112868

Description

Protein Tyrosine Phosphatase Polyclonal Antibody for Western Blot, ELISA

PRL-3 is a newly identified metastasis-related gene, which codes a 22 KDa non-classical protein tyrosine phosphatase with a C-terminal prenylation motif. It is located at the cytoplasmic membrane when prenylated and in the nucleus when nonpreylated. PRL-3 has at least 75% amino-acid sequence similarity with PRL-1 and PRL-2, the other two members of the PRL family. Recently, Zeng and colleagues found that Chinese hamster ovary cells stably expressing PRL-3 exhibited enhanced motility, invasive activity, and induced metastatic tumor formation in nude mice. And in clinical study, PRL-3 is consistently overexpressed in liver metastasis in colorectal cancer cells. These findings suggest PRL-3 is a new target for the early diagnosis of metastasis as well as the drug discovery.

Specifications

• Antigen: Protein Tyrosine Phosphatase
• Classification: Polyclonal
• Conjugate: Unconjugated
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Target Species: Zebrafish
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Concentration: 3.12 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Immunogen: Recombinant Zebrafish Protein tyrosine phosphatase, receptor type, s, a protein (269-424AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid