Invitrogen™ Protein Z Polyclonal Antibody

Catalog No.	Quantity
PIPA143060	1 mg

Catalog No. PIPA143060 Supplier Invitrogen™ Supplier No. PA143060

Description

Sheep Polyclonal Antibody

PA1-43060 detects Protein Z in human samples. PA1-43060 has successfully been used in Western blot and ELISA applications. PA1-43060 was derived from human protein Z.

PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency; there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.

Specifications

• Antigen: Protein Z
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: 50% water with 50% glycerol and no preservative
• Gene: PROZ
• Gene Accession No.: P22891
• Gene Alias: protein Z, vitamin K dependent plasma glycoprotein; protein Z, vitamin K-dependent plasma glycoprotein; PROZ; PZ; vitamin K-dependent protein Z; vitamin K-dependent protein Z precursor variant 1
• Gene Symbols: PROZ
• Host Species: Sheep
• Immunogen: Human Protein Z.
• Purification Method: SDS-PAGE
• Quantity: 1 mg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8858
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov