Invitrogen™ Human Prothrombin (Factor II) Native Protein

Description

Native Protein

RP-43087 contains native human Prothrombin protein. RP-43087 may be used as a positive control in many immunological assays. The product is of human blood/plasma origin. Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests. This product is to be used for IN VITRO research purposes only, and is not intended for clinical or diagnostic use!

Prothrombin or Coagulation factor II, is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

Specifications

• Accession Number: P00734
• Concentration: 8 mg/mL
• For Use With (Application): Control
• Formulation: 50% water with 50% glycerol and no preservative
• Gene ID (Entrez): 2147
• Molecular Weight (g/mol): 72 kDa
• Name: Human Prothrombin (Factor II)
• Quantity: 2 mg
• Source: Human
• Regulatory Status: RUO
• Gene Alias: Activation peptide fragment 1; Activation peptide fragment 2; bovine prothrombin protein; Cf2; Cf-2; coagulation factor 2; coagulation factor II; coagulation factor II (thrombin); coagulation factor II [thrombin]; coagulation factor II, thrombin; F2; FII; kringle-2 domain; fragment-2; prepro-coagulation factor II; preprothrombin; prothrombin; prothrombin B-chain; prothrombin precursor; PT; RPRGL2; serine protease; THPH1; THROMBIN; Thrombin heavy chain; Thrombin light chain
• Common Name: Prothrombin
• Gene Symbol: F2
• Biological Activity: Specific Activity = 6.7 U/mg; determined that 1 unit equals the prothrombin activity in 1 mL of normal human plasma.
• Conjugate: Unconjugated
• Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Protein Subtype: Native

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov