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Protocadherin gamma C3 Mouse anti-Human, Alexa Fluor 647, Clone: 926518, R&D Systems™

Mouse Monoclonal Antibody

Manufacturer:  R&D Systems FAB83641R025

Catalog No. FAB83641R02

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Description

Description

Protocadherin γ C3 is a member of the γ subgroup of clustered protocadherins (1). Like other γ protocadherins, mature Protocadherin γ C3 contains six extracellular cadherin domains, a transmembrane region, and a cytoplasmic domain (2, 3). Within the ECD, human Protocadherin γ C3 shares 91% and 92% amino acid sequence identity with mouse and rat Protocadherin γ C3, respectively. It plays an important role in cell adhesion and cell recognition through Ca2+ -dependent homophilic interaction (4). MMP-mediated shedding of γ protocadherins and release of their cytoplasmic domain by the γ-secretase complex results in translocation of the intracellular domain into the nucleus and transcriptional activation of target genes (5-7). Protocadherin γ C3 is cleaved within its ectodomain by ADAM10 in fibroblasts and neuronal cells (8). Deletion of the entire protocadherin γ gene cluster is embryonic lethal in mice (9). Protocadherin γ C3 is most notably expressed in the nervous system (10). Conditional deletion of the protocadherin γ gene cluster in mice affects development of retinal ganglion cells and spinal cord interneurons, resulting in decreased synapses and increased neuronal apoptosis (9, 11-14). The C-type protocadherin γ isoforms specifically may be responsible for the increased apoptosis observed in mice lacking the entire protocadherin γ gene cluster (15). Cortical neuron-specific deletion of the protocadherin γ gene cluster results in dendritic arborization defects (16). The protocadherin γ subfamily may also be involved in cerebrospinal fluid production and the maturation and differentiation of postnatally generated olfactory granule cells (17, 18).
Specifications

Specifications

Protocadherin gamma C3
926518
Flow Cytometry 5 uL/10^6 cells
Q9UN70
cadherin-like 2, PC43, PC-43, PCDH2, PCDH-GAMMA-C3, PCDHGC3, protocadherin 2, protocadherin 43, protocadherin gamma subfamily C, 3, protocadherin gamma-C3, protocadherin-2, Protocadherin-43
Mouse
IgG1
25 Tests
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied.
Monoclonal
Detects human Protocadherin gamma C3 in direct ELISAs.
Flow Cytometry
Alexa Fluor 647
Supplied in a saline solution containing BSA and Sodium Azide. with Sodium Azide
Purified
PCDHGC3
Chinese hamster ovary cell line CHO-derived recombinant human Protocadherin gamma C3 Met1-Tyr693 Accession # Q9UN70
Protein A or G purified from hybridoma culture supernatant
RUO
Primary
5098
Human
SDS
Documents
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