Invitrogen™ Proximal Nephrogenic Renal Antigen Monoclonal Antibody (PN-15 (66.4.C2))

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA135774

Catalog No. MA135774

Description

PN-15 reacts with a lectin receptor like glycoprotein of 200 kDa (gp200), present in proximal renal tubules and on urothelium. The antigen is carbohydrate in nature. Other normal tissues that display the antigen include breast, parathyroid glands, thymus and epididymis. Among renal carcinomas 93% of primary and 84% of metastatic carcinomas are positive. Bladder cancers are also largely positive. Other tumor types include breast cancer, teratocarcinomas and parathyroid adenomas. The antigen, also called DEC-205, was assigned to CD205 at CD workshop VII. In the immune system it can facilitate tolerance to self-antigens through uptake of apoptosis derived material by dendritic cells, which in turn present fragments through MHC II and MHC I, either inducing or repressing immune responses, depending on the nature of concomitant signals.

PNRA is a 200 kDa glycoprotein found in proximal renal tubules, and may be useful in characterizing renal cell carcinomas.

Specifications

• Antigen: Proximal Nephrogenic Renal Antigen
• Classification: Monoclonal
• Concentration: 0.1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Host Species: Mouse
• Purification Method: Purified
• Regulatory Status: RUO
• Target Species: Human, Rat, Monkey, Horse
• Product Type: Antibody
• Isotype: IgG2b κ

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Clone: PN-15 (66.4.C2)
• Conjugate: Unconjugated
• Gene Alias: PNRA
• Immunogen: Renal cortical tissue extract.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: 4°C
• Form: Liquid