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Invitrogen™ PrP Monoclonal Antibody (1.5D7)
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Catalog No. FERMA549089
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100 μg
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FERMA549089 100 μg
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Catalog No. FERMA549089 Supplier Invitrogen™ Supplier No. MA549089
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Description

Mouse Monoclonal Antibody

PrP Monoclonal Antibody for IHC (F), IHC (P), Inhibition, Western Blot

Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PrP
Applications Inhibition Assays, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 1.5D7
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and 0.02% sodium azide
Gene PRNP
Gene Accession No. P10279
Gene Alias AA960666; AI325101; Alternative prion protein; alternative prion protein; major prion protein; AltPrP; ASCR; BSE; CD230; CD230 antigen; CJD; GSS; KURU; major prion protein; major prion protein; alternative prion protein; major scrapie-associated fibril protein 1; MGC26679; p27-30; PK resistant core; prion protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein precursor; prion protein precursor PrP; prion protein PrP; prion protein variant a; prion protein variant b; prion protein, PrP; prion protein, structural; prion-related protein; PRIP; Prn; Prn-i; Prnp; Prn-p; PrP; PrP>C>; PrP27-30; PrP33-35C; PrPc; PrPSc; Sinc; SIP; TSE
Gene Symbols PRNP
Host Species Mouse
Immunogen The monoclonal antibody 1.5D7 recognizes the disease associated isoform of the prion protein termed PrPSc.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 281427
Target Species Bovine
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2b
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