Invitrogen™ PrP Recombinant Rabbit Monoclonal Antibody (3D0J9)

Catalog No.	Quantity
PIMA535724	100 μL

Catalog No. PIMA535724 Supplier Invitrogen™ Supplier No. MA535724

Description

Rabbit Recombinant Monoclonal Antibody

Immunogen sequence: MHRYPNQVYY RPMDEYSNQN NFVHDCVNIT IKQHTVTTTT KGENFTETDV KMMERVVEQM CITQYERESQ AYYQRGSSMV LFSSPPVILL ISFLIFLIVG.

Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.

Specifications

• Antigen: PrP
• Applications: ELISA, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 3D0J9
• Concentration: 0.4 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: PRNP
• Gene Accession No.: F7VJQ1, P04156, P04925, P13852
• Gene Alias: AA960666; AI325101; Alternative prion protein; alternative prion protein; major prion protein; AltPrP; ASCR; BSE; CD230; CD230 antigen; CJD; GSS; KURU; major prion protein; major prion protein; alternative prion protein; major scrapie-associated fibril protein 1; MGC26679; p27-30; PK resistant core; prion protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein precursor; prion protein precursor PrP; prion protein PrP; prion protein variant a; prion protein variant b; prion protein, PrP; prion protein, structural; prion-related protein; PRIP; Prn; Prn-i; Prnp; Prn-p; PrP; PrP>C>; PrP27-30; PrP33-35C; PrPc; PrPSc; Sinc; SIP; TSE
• Gene Symbols: PRNP
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 154-253 of human Prion Protein (P04156).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 19122, 24686, 5621
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG