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Invitrogen™ PrP Polyclonal Antibody
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Catalog No. PIPA527313
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100 μL
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PIPA527313 100 μL
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Catalog No. PIPA527313 Supplier Invitrogen™ Supplier No. PA527313
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: IMR32, Neuro2A, NIH-3T3, C2C12. Predicted reactivity: Mouse (89%), Rat (89%), Dog (88%), Pig (90%), Rabbit (91%), Sheep (90%), Rhesus Monkey (95%), Chimpanzee (98%), Bovine (87%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PrP
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.36 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene PRNP
Gene Accession No. F7VJQ1, P04156, P04925
Gene Alias AA960666; AI325101; Alternative prion protein; alternative prion protein; major prion protein; AltPrP; ASCR; BSE; CD230; CD230 antigen; CJD; GSS; KURU; major prion protein; major prion protein; alternative prion protein; major scrapie-associated fibril protein 1; MGC26679; p27-30; PK resistant core; prion protein; prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia); prion protein precursor; prion protein precursor PrP; prion protein PrP; prion protein variant a; prion protein variant b; prion protein, PrP; prion protein, structural; prion-related protein; PRIP; Prn; Prn-i; Prnp; Prn-p; PrP; PrP>C>; PrP27-30; PrP33-35C; PrPc; PrPSc; Sinc; SIP; TSE
Gene Symbols PRNP
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human Prion Protein (PrP). The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19122, 5621
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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