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Invitrogen™ PRPK Polyclonal Antibody
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Catalog No. PIPA582542
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100 μL
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PIPA582542 100 μL
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Catalog No. PIPA582542 Supplier Invitrogen™ Supplier No. PA582542
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AAVIKHRFPK GYRHPALEAR LGRRRTVQEA RALLRCRRAG ISAPVVFFVD YASNCLYMEE IEGSVTVRDY IQSTMETEKT PQGLSNLAKT IGQV Highest antigen sequence indentity to the following orthologs: Mouse - 87%, Rat - 87%.

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen PRPK
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Tp53rk
Gene Accession No. Q96S44
Gene Alias 2810408M09Rik; 4933401B08Rik; 5630401H01Rik; Atypical serine/threonine protein kinase TP53RK; BUD32; C20orf64; dJ101A2; EKC/KEOPS complex subunit TP53RK; mNori-2p; Nori-2; Nori-2p; p53-related protein kinase; PRPK; TP53 regulating kinase; TP53-regulating kinase; TP53RK; transformation related protein 53 regulating kinase; Trp53 regulating kinase; Trp53rk; Trp53tk
Gene Symbols Tp53rk
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human TP53RK. Recombinant protein control fragment (Product #RP-89811).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 112858
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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