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Invitrogen™ PRR5L Polyclonal Antibody
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Catalog No. PIPA567089
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100 μL
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PIPA567089 100 μL
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Catalog No. PIPA567089 Supplier Invitrogen™ Supplier No. PA567089
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RQCSSEPNITD NPDGLEEGAR GSQEGSELNC ASLS Highest antigen sequence identity to the following orthologs - mouse 73%, rat 73%.

Proline-rich protein 5-like (PRR5L), also known as Protor-2, is structurally similar to PRR5 and also binds to the mTOR complex 2 (mTORC2). PRR5L is not required for mTORC2 integrity or kinase activity, but dissociates from mTORC2 upon knockdown of tuberous sclerosis complex 1 (TSC1) and TSC2. Knockdown of PRR5L reduced apoptosis in mTORC2 deficient cells as well as cells where mTOR was active, suggesting that mTORC2-dissociated PRR5L may promote apoptosis, and thus play a role in the balance between cell growth and cell death.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PRR5L
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PRR5L
Gene Accession No. Q6MZQ0
Gene Alias 2600010E01Rik; 4833411O04Rik; proline rich 5 like; proline-rich protein 5-like; Protein observed with Rictor-2; PROTOR2; protor-2; Prr5l
Gene Symbols PRR5L
Host Species Rabbit
Immunogen Recombinant Human PRR5L. Recombinant protein control fragment (Product #RP-107733).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79899
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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