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Invitrogen™ PRSS21 Polyclonal Antibody
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Catalog No. PIPA547879
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100 μg
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PIPA547879 100 μg
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Catalog No. PIPA547879 Supplier Invitrogen™ Supplier No. PA547879
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Description

Goat Polyclonal Antibody

This antibody detects recombinant mouse Testisin/Prss21 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant mouse (rm) Prss8 and rmPrss27 is observed. Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

PRSS21, also known as testisin, is a serine protease gene located on human chromosome 16p13.3. This gene is primarily expressed in the testes, where it plays a significant role in spermatogenesis, particularly during the development and maturation of sperm cells. Structurally, PRSS21 encodes a glycosylphosphatidylinositol (GPI)-anchored serine protease, a feature that helps localize it to the cell surface, facilitating its involvement in cell signaling and proteolytic pathways. While research into PRSS21 remains ongoing, its specific function is believed to be related to remodeling the extracellular matrix during sperm development, impacting fertility. Beyond reproductive roles, alterations in PRSS21 expression have been observed in some cancer types, such as testicular germ cell tumors, suggesting its potential role as a biomarker for certain malignancies. This dual functionality underscores its importance not only in reproductive biology but also within oncology research.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PRSS21
Applications Immunohistochemistry (Frozen), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Prss21
Gene Accession No. Q9JHJ7
Gene Alias 1700023E12Rik; EC 3.4.21; eosinophil serine protease 1; eosinophil serine protease-1; ESP1; ESP-1; mT4; protease, serine 21; protease, serine, 21; protease, serine, 21 (testisin); PRSS21; Resp-1; Serine protease 21; serine protease from eosinophils; TESP5; TEST1; TEST1testisin; testicular serine protease 5; testisin; Tryptase 4; UNQ266/PRO303
Gene Symbols Prss21
Host Species Goat
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse Testisin/Prss21 Gln28-Asn298.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 353251, 57256
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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