Invitrogen™ PRSS21 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA547879

Catalog No. PIPA547879

Description

This antibody detects recombinant mouse Testisin/Prss21 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant mouse (rm) Prss8 and rmPrss27 is observed. Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

PRSS21, also known as testisin, is a serine protease gene located on human chromosome 16p13.3. This gene is primarily expressed in the testes, where it plays a significant role in spermatogenesis, particularly during the development and maturation of sperm cells. Structurally, PRSS21 encodes a glycosylphosphatidylinositol (GPI)-anchored serine protease, a feature that helps localize it to the cell surface, facilitating its involvement in cell signaling and proteolytic pathways. While research into PRSS21 remains ongoing, its specific function is believed to be related to remodeling the extracellular matrix during sperm development, impacting fertility. Beyond reproductive roles, alterations in PRSS21 expression have been observed in some cancer types, such as testicular germ cell tumors, suggesting its potential role as a biomarker for certain malignancies. This dual functionality underscores its importance not only in reproductive biology but also within oncology research.

Specifications

• Antigen: PRSS21
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Prss21
• Gene Alias: 1700023E12Rik; EC 3.4.21; eosinophil serine protease 1; eosinophil serine protease-1; ESP1; ESP-1; mT4; protease, serine 21; protease, serine, 21; protease, serine, 21 (testisin); PRSS21; Resp-1; Serine protease 21; serine protease from eosinophils; TESP5; TEST1; TEST1testisin; testicular serine protease 5; testisin; Tryptase 4; UNQ266/PRO303
• Host Species: Goat
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 353251, 57256
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q9JHJ7
• Gene Symbols: Prss21
• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Testisin/Prss21 Gln28-Asn298.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG