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Tocris Bioscience™ PRT 4165
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Catalog No. 504710R
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50 mg
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504710R 10 mg
504750R 50 mg
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Catalog No. 504710R Supplier Tocris Bioscience™ Supplier No. 5047/10
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Description

Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination

PRT 4165 is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1); inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α (Top2α). Also shown to inhibit the in vitro E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex, inhibiting H2A/H2AX ubiquitination. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro.

Specifications

Quantity 10 mg
Product Type PRT 4165
Purity >99%
Molecular Weight (g/mol) 235.24
Inhibitors PRT 4165

For Research Use Only

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