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Invitrogen™ PRTFDC1 Polyclonal Antibody
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Catalog No. PA551329
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100 μL
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PA551329 100 μL
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Catalog No. PA551329 Supplier Invitrogen™ Supplier No. PA551329
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total PRTFDC1 protein.

Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PRTFDC1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene PRTFDC1
Gene Accession No. Q9NRG1
Gene Alias HHGP; phosphoribosyl transferase domain containing 1; phosphoribosyltransferase domain-containing protein 1; PRTFDC1
Gene Symbols PRTFDC1
Host Species Rabbit
Immunogen Full length fusion protein of human PRTFDC1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56952
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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