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PRTFDC1 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501984322
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50-198-4322 100 μL
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Catalog No. 50-198-4322 Supplier Bioss Supplier No. BS19446R
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Description

Rabbit Polyclonal Antibody

Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.

Specifications

Antigen PRTFDC1
Applications Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene PRTFDC1
Gene Accession No. Q9NRG1
Gene Alias HHGP; phosphoribosyl transferase domain containing 1; Phosphoribosyltransferase domain-containing protein 1; PRTFDC1
Gene Symbols PRTFDC1
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human PRTFDC1.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56952
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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