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Tocris Bioscience™ PS 1145 dihydrochloride Available on GSA/VA Contract for Federal Government customers only.

Selective IKK inhibitor; orally active

Manufacturer:  Tocris Bioscience™ 4569/10

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Catalog No. 45-691-0


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Description

Description

Selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active.

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