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Tocris™ PS 1145 dihydrochloride

Selective IKK inhibitor; orally active

Manufacturer:  Tocris™ 4569/50

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Catalog No. 45-695-0

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For Research Use Only



Selective IκB kinase (IKK) inhibitor (IC50 = 100nM). Has no effect on PKA, PKC and CKII activity. Inhibits IκB-α phosphorylation and NFκB activation in HeLa cells. Inhibits NFκB-mediated proinflammatory gene expression in human airway epithelial cells. Enhances TNF-α-induced apoptosis in a multiple myeloma cell line. Attenuates LPS-induced TNF-α production in vivo. Orally active.
  • Chemical Name: N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride
  • Formula: C17H11ClN4O.2HCl
  • CAS Number: 1049743-58-9
  • Solubility: Soluble to 5mM in DMSO with gentle warming
  • Purity: >98
Description & Specifications


PS 1145 dihydrochloride
PS 1145 dihydrochloride
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