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  5. Tocris Bioscience™ PSEM 308 hydrochloride

Tocris Bioscience™ PSEM 308 hydrochloride
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Catalog No. 642525
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25 mg
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64-252-5 25 mg
64-255 5 mg
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Catalog No. 64-252-5 Supplier Tocris Bioscience™ Supplier No. 6425/25
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Description

PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist

PSEM 308 hydrochloride is a PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels.

Recommended concentration for use in mice is 5 mg/kg or lower.

Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.

Specifications

Chemical Name or Material 5-Methyl-5,8,9,10,11 A,12-hexahydro-4 H-8,11-ethanopyrido[3 ',2 ':3,4 ]diazepino[6,7,1-hi]indole hydrochloride
Quantity 25 mg
Target Pharmacologically Selective Effector Molecules/PSEM
Molecular Formula C17H21N3.HCl
Formula Weight 303.83
Purity 98%
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