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Tocris Bioscience™ PSEM 89S

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Quantity:
5 mg
25 mg
Description
PSEM 89S is a PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist (EC50 values are 3.4 and 2.2 μM, respectively). Activates cortical neurons expressing PSAML141F,Y115F-5-HT3 chimeric ion channels and inhibits activity of neurons expressing PSAML141F-GlyR in vitro. Silences hypothalamic AGRP neurons transfected with PSAML141F-GlyR chimeric ion channels in mice in vivo, leading to suppression of feeding. Brain penetrant.
Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.
Specifications
Specifications
Chemical Name or Material | N-(3 S)-1-Azabicyclo[2.2.2 ]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate |
CAS | 1336913-03-1 |
Quantity | 25 mg |
Target | Pharmacologically Selective Effector Molecules/PSEM |
Molecular Formula | C16H22N2O3.CF3CO2H |
Formula Weight | 404.38 |
Purity | 98% |
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