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Invitrogen™ PSMA Recombinant Rabbit Monoclonal Antibody (SP29)
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Catalog No. PIMA514579
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PIMA514579 1 mL
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Catalog No. PIMA514579 Supplier Invitrogen™ Supplier No. MA514579
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Description

Rabbit Recombinant Monoclonal Antibody

MA5-14579 targets Prostate Specific Membrane Antigen in IHC (P) applications and shows reactivity with Human samples. The MA5-14579 immunogen is c-terminal of Prostate Specific Membrane Antigen.

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PSMA
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Recombinant Monoclonal
Clone SP29
Concentration 0.11 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA and 0.1% sodium azide; pH 7.2
Gene FOLH1
Gene Accession No. Q04609
Gene Alias Cell growth-inhibiting gene 27 protein; FGCP; folate hydrolase (prostate-specific membrane antigen) 1; folate hydrolase 1; FOLH; Folh1; Folylpoly-gamma-glutamate carboxypeptidase; GCP2; GCPII; GIG27; glutamate carboxylase II; glutamate carboxypeptidase 2; Glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; mGCP; mopsm; Naalad; NAALAD1; NAALAdase; NAALADase I; N-acetylated alpha-linked acidic dipeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I; prostate specific membrane antigen; prostate specific membrane antigen variant F; prostate-specific membrane antigen; Prostate-specific membrane antigen homolog; PSM; PSMA; pteroylpoly-gamma-glutamate carboxypeptidase
Gene Symbols FOLH1
Host Species Rabbit
Immunogen C-terminal of Prostate Specific Membrane Antigen.
Purification Method Protein A
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2346
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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