Invitrogen™ PSMA Recombinant Rabbit Monoclonal Antibody (SP29)

Catalog No.	Quantity
PIMA516395	500 μL

Catalog No. PIMA516395 Supplier Invitrogen™ Supplier No. MA516395

Description

Rabbit Recombinant Monoclonal Antibody

Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is prostate carcinoma.

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.

Specifications

• Antigen: PSMA
• Applications: Immunohistochemistry (Paraffin)
• Classification: Recombinant Monoclonal
• Clone: SP29
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA and 0.1% sodium azide; pH 7.6
• Gene: FOLH1
• Gene Accession No.: Q04609
• Gene Alias: Cell growth-inhibiting gene 27 protein; FGCP; folate hydrolase (prostate-specific membrane antigen) 1; folate hydrolase 1; FOLH; Folh1; Folylpoly-gamma-glutamate carboxypeptidase; GCP2; GCPII; GIG27; glutamate carboxylase II; glutamate carboxypeptidase 2; Glutamate carboxypeptidase II; membrane glutamate carboxypeptidase; mGCP; mopsm; Naalad; NAALAD1; NAALAdase; NAALADase I; N-acetylated alpha-linked acidic dipeptidase; N-acetylated alpha-linked acidic dipeptidase 1; N-acetylated-alpha-linked acidic dipeptidase I; prostate specific membrane antigen; prostate specific membrane antigen variant F; prostate-specific membrane antigen; Prostate-specific membrane antigen homolog; PSM; PSMA; pteroylpoly-gamma-glutamate carboxypeptidase
• Gene Symbols: FOLH1
• Host Species: Rabbit
• Immunogen: Synthetic peptide derived from C-terminus of human PSMA.
• Purification Method: Protein A
• Quantity: 500 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2346
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG