PSMA1 Polyclonal Antibody, Invitrogen™

Catalog No.	Quantity
PIPA596150	100 μL

Catalog No. PIPA596150 Supplier Thermo Scientific Supplier No. PA596150

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MFRNQYDNDV TVWSPQGRIH QIEYAMEAVK QGSATVGLKS KTHAVLVALK RAQSELAAHQ KKILHVDNHI GISIAGLTAD ARLLCNFMRQ ECLDSRFVFD RPLPVSRLVS LIGSKTQIPT QRYGRRPYGV GLLIAGYDDM GPHIFQTCPS ANYFDCRAMS IGARSQSART YLERHMSEFM ECNLNELVKH GLRALRETLP AEQDLTTKNV SIGIVGKDLE FTIYDDDDVS PFLEGLEERP QRKAQPAQPA DEPAEKADEP MEH; Positive Samples: 293T, Jurkat, HeLa, HepG2, U-251MG, SW620, Mouse liver, Mouse heart, Mouse spleen; Cellular Location: Cytoplasm, Nucleus

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (approximately31), barrel-shaped molecular machine with an apparent molecular weight of approximately2. 5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.

Specifications

• Antigen: PSMA1
• Applications: Immunocytochemistry, Western Blot
• Classification: Polyclonal
• Concentration: 1.56 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
• Gene: PSMA1
• Gene Accession No.: P18420, P25786, Q9R1P4
• Gene Alias: 20S proteasome subunit C2, 30 kDa prosomal protein, alpha-type, C2, epididymis secretory protein Li 275, HC2, HEL-S-275, macropain subunit C2, macropain subunit nu, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915, multicatalytic endopeptidase complex subunit C2, NU, PROS30, PROS-30, proteasome (prosome, macropain) subunit, alpha type 1, proteasome (prosome, macropain) subunit, alpha type, 1, proteasome 20S subunit alpha 1, proteasome alpha 1 subunit, proteasome component C2, Proteasome nu chain, proteasome subunit alpha 1, Proteasome subunit alpha type-1, proteasome subunit nu, proteasome subunit, alpha-type, 1, protein P30-33K, PSC2, Psma1, testicular tissue protein Li 150
• Gene Symbols: PSMA1
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-263 of human PSMA1 (NP_0027771)
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 26440, 29668, 5682
• Target Species: Human, Mouse, Rat
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov