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Invitrogen™ PSMA7 Polyclonal Antibody
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Catalog No. PIPA5115804
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PIPA5115804 100 μL
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Catalog No. PIPA5115804 Supplier Invitrogen™ Supplier No. PA5115804
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total PSMA7.

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PSMA7
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene PSMA7
Gene Accession No. O14818, Q9Z2U0
Gene Alias C6; C6-I; epididymis secretory protein Li 276; HEL-S-276; HSPC; proteasome (prosome, macropain) subunit, alpha type 7; proteasome (prosome, macropain) subunit, alpha type, 7; proteasome subunit alpha 4; proteasome subunit alpha 7; proteasome subunit alpha type-7; Proteasome subunit RC6-1; proteasome subunit XAPC7; Psma7; RC6-1; RP5-1005F21.4; testicular tissue protein Li 151; XAPC7
Gene Symbols PSMA7
Host Species Rabbit
Immunogen A synthesized peptide derived from human PSMA7(Accession O14818), corresponding to amino acid residues R117-S167.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26444, 5688
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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