Invitrogen™ PSMA8 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589783

Catalog No. PIPA589783

Description

Immunogen sequence: MASRYDRAIT VFSPDGHLFQ VEYAQEAVKK GSTAVGIRGT NIVVLGVEKK SVAKLQDERT VRKICALDDH VCMAFAVLTI FIGLTADARV VINRARVECQ SHKLTVEDPV TVEYITRFIA TLKQKYTQSN GRRPFGISAL IVGFDDDGIS RLYQTDPSGT YHAWKANAIG RSAKTVREFL EKNYTEDAIA SDSEAIKLAI KALLEVVQSG GKNIELAIIR RNQPLKMFSA KEVELYVTEI; Positive Samples: K-562, Mouse thymus, Mouse testis, Rat testis; Cellular Location: Cytoplasm, Nucleus.

Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complexe that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I. [UniProt].

Specifications

• Antigen: PSMA8
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PSMA8
• Gene Alias: 2410072D24Rik; proteasome (prosome, macropain) subunit, alpha type, 8; proteasome 20S subunit alpha 8; proteasome alpha 8 subunit; proteasome subunit alpha 8; proteasome subunit alpha type 7; proteasome subunit alpha type 7-like protein variant 1; proteasome subunit alpha type-7-like; Proteasome subunit alpha-type 7-like; Proteasome subunit alpha-type 8; psma7; PSMA7L; PSMA8; RGD1311659; wu:fk28c01; zgc:77139
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 143471, 364814, 73677
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.33 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q8TAA3, Q9CWH6
• Gene Symbols: PSMA8
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PSMA8 (NP_6532632).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG