Invitrogen™ PSMB10 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556403

Catalog No. PIPA556403

Description

Immunogen sequence: FRYQGHVGAS LIVGGVDLTG PQLYGVHPHG SYSRLPFTAL GSGQDAALAV LEDRFQPNMT LEAAQGLLVE AVT Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 92%.

The 20S proteasome is a protease complex that is responsible for cytosolic protein degradation and generation of peptide ligands for major histocompatibility complex (MHC) class I molecules, either in their final form or in the form of amino-terminally extended precursors. Upon IFN-gamma stimulation of cells, three constitutively expressed subunits of the 20S proteasome are replaced by inducible subunits LMP2 (low-molecular mass polypeptide 2), LMP7, and MECL-1 (multicatalytic endopeptidase complex-like-1, LMP10). LMP2, LMP7, and MECL-1 subunits form immunoproteasomes, which are associated with more efficient class I antigen processing and presentation. Independent assortment of LMP-2, LMP-7, and MECL-1 into different proteasome complexes can lead to 36 unique proteasome subsets, which may mediate differences in the cleavage specificities/cleavage motifs of proteins subject to constitutive- and immuno-proteasomes.

Specifications

• Antigen: PSMB10
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PSMB10
• Gene Alias: beta2i; LMP10; Low molecular mass protein 10; macropain; Macropain subunit MECl-1; MECL1; Mecl-1; MGC1665; multicatalytic endopeptidase complex subunit MECl-1; OTTHUMP00000174858; prosome; prosome Mecl1; proteasome (prosome, macropain) subunit, beta type 10; proteasome (prosome, macropain) subunit, beta type, 10; proteasome (prosomome, macropain) subunit, beta type 10; proteasome 20S subunit beta 10; proteasome beta 10 subunit; proteasome catalytic subunit 2i; Proteasome MECl 1; proteasome MECl-1; proteasome subunit 10; proteasome subunit beta 10; proteasome subunit beta 7i; proteasome subunit beta type-10; Proteasome subunit beta-2i; proteasome subunit LMP10; proteasome subunit MECL1; PSMB 10; Psmb10
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5699
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P40306
• Gene Symbols: PSMB10
• Immunogen: Recombinant protein corresponding to Human PSMB10. Recombinant protein control fragment (Product #RP-102567).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG