Invitrogen™ PSMB7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530988

Catalog No. PIPA530988

Description

Recommended positive controls: A549, HeLa, HepG2, HCT116, mouse brain. Predicted reactivity: Mouse (96%), Rat (95%), Dog (95%), Pig (93%), Chicken (84%), Rhesus Monkey (98%), Bovine (95%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit).

Specifications

• Antigen: PSMB7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Psmb7
• Gene Alias: AU020723; beta-type proteasome 7 subunit; EGK_07890; hypothetical protein LOC511207; macropain chain Z; MC14; Mmc14; Multicatalytic endopeptidase complex chain Z; proteasome (prosome, macropain) subunit, beta type 7; proteasome (prosome, macropain) subunit, beta type, 7; proteasome 20S subunit beta 7; proteasome beta 7 subunit; proteasome catalytic subunit 2; proteasome subunit alpha; proteasome subunit beta 7; proteasome subunit beta type-7; proteasome subunit beta type-7 proprotein; proteasome subunit Z; protein serine kinase c17; Psmb7; RP11-101K10.7; Z
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19177, 5695
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P70195, Q99436
• Gene Symbols: Psmb7
• Immunogen: Recombinant fragment corresponding to a region within amino acids 85 and 277 of Human Proteasome 20S beta 7.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov