Invitrogen™ PSMB8 Monoclonal Antibody (1A5)

Catalog No.	Quantity
PIMA515890	100 μL

Catalog No. PIMA515890 Supplier Invitrogen™ Supplier No. MA515890

Description

Mouse Monoclonal Antibody

MA5-15890 targets PSMB8 in indirect ELISA, IF, IHC, and WB applications and shows reactivity with Human and rat samples. The MA5-15890 immunogen is purified recombinant fragment of human PSMB8 expressed in E. Coli. . MA5-15890 detects PSMB8 which has a predicted molecular weight of approximately 30kDa.

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.

Specifications

• Antigen: PSMB8
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 1A5
• Concentration: Conc. Not Determined
• Conjugate: Unconjugated
• Formulation: ascites with 0.03% sodium azide
• Gene: Psmb8
• Gene Accession No.: P28062, P28064
• Gene Alias: ALDD; D6S216; D6S216E; DAAP-57C1.3; JMP; large multifunctional protease 7; Lmp7; Lmp-7; low molecular mass polypeptide 7; low molecular mass protein 7; low molecular weight protein 7; macropain subunit C13; Mc13; MC13 (LMP7); MGC1491; multicatalytic endopeptidase complex subunit C13; NKJO; OTTHUMP00000029420; OTTHUMP00000029421; OTTHUMP00000062981; protease component C13; proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteasome (prosome, macropain) subunit, beta type, 8; proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7); proteasome catalytic subunit 3i; proteasome component C13; proteasome subunit beta 5i; proteasome subunit beta 8; proteasome subunit beta type 8; proteasome subunit beta type-8; Proteasome subunit beta-5i; proteasome subunit MC13; proteasome subunit Y2; proteasome-related gene 7; proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteosome beta 8 subunit; PSMB5i; Psmb8; Really interesting new gene 10 protein; Ring10; Y2
• Gene Symbols: Psmb8
• Host Species: Mouse
• Immunogen: Purified recombinant fragment of human PSMB8 expressed in E. Coli.
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 24968, 5696
• Target Species: Human, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1