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Invitrogen™ PSMC4 Polyclonal Antibody
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Catalog No. PIPA596144
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100 μL
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PIPA596144 100 μL
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Catalog No. PIPA596144 Supplier Invitrogen™ Supplier No. PA596144
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MEEIGILVEK AQDEIPALSV SRPQTGLSFL GPEPEDLEDL YSRYKKLQQE LEFLEVQEEY IKDEQKNLKK EFLHAQEEVK RIQSIPLVIG QFLEAVDQNT AIVGSTTGSN YYVRILSTID RELLKPNASV ALHKHSNALV DVLPPEADSS IMMLTSDQKP DVMYA; Positive Samples: HepG2, U-251MG, 293T, BT-474, A-549, HeLa, Jurkat, Mouse liver, Mouse heart; Cellular Location: Cytoplasm, Nucleus.

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PSMC4
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.31 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene PSMC4
Gene Accession No. P43686, P54775, Q63570
Gene Alias 26S protease regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; 26S proteasome regulatory subunit 6B; CAR interacing protein 21; CAR interacting protein 21; CIP21; MB67-interacting protein; MGC13687; MGC23214; MGC8570; MIP224; protease 26S subunit 6; proteasome (prosome, macropain) 26S subunit, ATPase, 4; proteasome 26S ATPase subunit 4; proteasome 26S subunit ATPase 4; proteasome 26S subunit, ATPase 4; PSMC4; RPT3; S6; S6 ATPase; Tat-binding protein 7; TBP7; TBP-7
Gene Symbols PSMC4
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-165 of human PSMC4 (NP_0064941).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117262, 23996, 5704
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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