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PSMC4 Polyclonal Antibody, Bethyl Laboratories

Catalog No. 501566225
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Catalog No. Quantity
50-156-6225 20 μL
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Catalog No. 50-156-6225 Supplier Bethyl Laboratories, Inc Supplier No. A303850AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predict

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified.

Specifications

Antigen PSMC4
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation TBS with 0.1% BSA and 0.09% sodium azide
Gene PSMC4
Gene Accession No. P43686
Gene Alias MIP224, S6, TBP7, 26S protease regulatory subunit 6B, 26S proteasome AAA-ATPase subunit RPT3, MB67 interacting protein, MB67-interacting protein, TBP-7, Tat-binding protein 7, protease 26S subunit 6, proteasome 26S subunit ATPase 4
Gene Symbols PSMC4
Host Species Rabbit
Immunogen Between 368 and 418
Purification Method Antigen affinity chromatography
Quantity 20 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5704
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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