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Invitrogen™ PSMD14 Polyclonal Antibody
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Catalog No. PIPA588037
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100 μL
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PIPA588037 100 μL
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Catalog No. PIPA588037 Supplier Invitrogen™ Supplier No. PA588037
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FRLINANMMV LGHEPRQTTS NLGHLNKPSI QALIHGLNRH YYSITINYRK NELEQKMLLN LHKKSWMEGL TLQDYSEHCK HNESVVKEML ELAKNYNKAV EEEDKMTPEQ LAIKNVGKQD PKRHLEEHVD VLMTSNIVQC L; Positive Samples: HepG2, HeLa, A-549, 293T, Raji, Mouse heart, Mouse kidney, Mouse liver.

The 26S proteasome is responsible for most intracellular proteolysis in eukaryotes. POH1 (also known as Rpn11 in yeast) subunit of the 19S complex is responsible for substrate deubiquitination during proteasomal degradation. POH1 appears to be a Zn21-dependent protease, unlike all other known deubiquitinating enzymes (DUBs) that are cysteine proteases. POH1 was first identified as the human functional homolog of the S. pombe pad1 gene, which confers moderate resistance to chemotherapeutic drugs, and also to ultraviolet light when transiently overproduced in mammalian cells. Poh1-induced drug resistance is mediated through AP-1 transcription factors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PSMD14
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.37 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene PSMD14
Gene Accession No. O00487, O35593
Gene Alias 2610312C03Rik; 26S proteasome non-ATPase regulatory subunit 14; 26S proteasome non-ATPase subunit; 26S proteasome regulatory subunit rpn11; 26S proteasome-associated pad1 homolog; 26S proteasome-associated PAD1 homolog 1; 3200001M20Rik; AA986732; MAD1; PAD1; POH1; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; proteasome 26S subunit, non-ATPase 14; Psmd14; rpm11; RPN11; testis tissue sperm-binding protein Li 69n
Gene Symbols PSMD14
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 160-300 of human PSMD14 (NP_0057961).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10213, 311078, 59029
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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