Invitrogen™ PSMD2 Polyclonal Antibody

Catalog No.	Quantity
PIPA527663	100 μL

Catalog No. PIPA527663 Supplier Invitrogen™ Supplier No. PA527663

Description

Rabbit Polyclonal Antibody

Recommended positive controls: A431, JC, BCL-1. Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (91%), Xenopus laevis (92%), Pig (100%), Chicken (97%), Bovine (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1.

Specifications

• Antigen: PSMD2
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.82 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene: PSMD2
• Gene Accession No.: Q13200, Q8VDM4
• Gene Alias: 26S proteasome non-ATPase regulatory subunit 2; 26S proteasome non-ATPase regulatory subunit 2-like protein; 26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; 9430095H01Rik; AA407121; F23F1.8; I79_017809; MGC14274; P97; proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; proteasome 26S subunit, non-ATPase 2; protein 55.11; PSMD2; RPN1; S2; TEG-190; testis expressed gene 190; Tex190; TNFR-associated protein 2; TRAP2; Tumor necrosis factor type 1 receptor-associated protein 2
• Gene Symbols: PSMD2
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the center region of human PSMD2. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 21762, 5708
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG