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Invitrogen™ PSMD7 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5144642

Catalog No. FEPA5144642


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Description

Description

Positive control: K562 cell lysate, mouse testis tissue lysate, Hela cell lysate, rat testis tissue lysate, rat brain tissue, human colon tissue. Predicted band size: 37 kDa Subcellular Location: Cytosol, extracellular exosome, extracellular region, nucleoplasm, nucleus.

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (approximately 31), barrel-shaped molecular machine with an apparent molecular weight of approximately 2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

PSMD7
Polyclonal
Unconjugated
Psmd7
26S proteasome non-ATPase regulatory subunit 7; 26S proteasome non-ATPase regulatory subunit 7-like protein; 26S proteasome regulatory subunit rpn8; 26S proteasome regulatory subunit S12; AW107203; Moloney leukemia virus-34 proviral integration; Mov34; Mov-34; Mov34 homolog; Mov34 protein; Mov34 protein homolog; MOV34L; P40; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog); proteasome 26S non-ATPase subunit 7; proteasome 26S subunit, non-ATPase 7; proteasome subunit p40; Psmd7; Rpn8; S12; wu:fi03c01; zgc:55284
Rabbit
Affinity chromatography
RUO
17463, 307821, 5713
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
P26516, P51665
Psmd7
Recombinant protein within Human PSMD7 aa 1-200/324.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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