Invitrogen™ PSMD7 Polyclonal Antibody

Catalog No.	Quantity
FEPA5144642	100 μL

Catalog No. FEPA5144642 Supplier Invitrogen™ Supplier No. PA5144642

Description

Rabbit Polyclonal Antibody

Positive control: K562 cell lysate, mouse testis tissue lysate, Hela cell lysate, rat testis tissue lysate, rat brain tissue, human colon tissue. Predicted band size: 37 kDa Subcellular Location: Cytosol, extracellular exosome, extracellular region, nucleoplasm, nucleus.

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (approximately 31), barrel-shaped molecular machine with an apparent molecular weight of approximately 2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.

Specifications

• Antigen: PSMD7
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene: Psmd7
• Gene Accession No.: P26516, P51665
• Gene Alias: 26S proteasome non-ATPase regulatory subunit 7; 26S proteasome non-ATPase regulatory subunit 7-like protein; 26S proteasome regulatory subunit rpn8; 26S proteasome regulatory subunit S12; AW107203; Moloney leukemia virus-34 proviral integration; Mov34; Mov-34; Mov34 homolog; Mov34 protein; Mov34 protein homolog; MOV34L; P40; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7; proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog); proteasome 26S non-ATPase subunit 7; proteasome 26S subunit, non-ATPase 7; proteasome subunit p40; Psmd7; Rpn8; S12; wu:fi03c01; zgc:55284
• Gene Symbols: Psmd7
• Host Species: Rabbit
• Immunogen: Recombinant protein within Human PSMD7 aa 1-200/324.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 17463, 307821, 5713
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG