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Invitrogen™ PSME4 Polyclonal Antibody
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Catalog No. PIPA589458
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100 μL
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PIPA589458 100 μL
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Catalog No. PIPA589458 Supplier Invitrogen™ Supplier No. PA589458
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Description

Rabbit Polyclonal Antibody

Positive Samples: MCF-7, U-87MG, 293T, HeLa, Mouse thymus, Mouse brain, Mouse heart, Mouse kidney, Rat liver; Cellular Location: Cytoplasm, Nucleus, Nucleus speckle, cytosol.

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen PSME4
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1.38 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene PSME4
Gene Accession No. Q14997, Q5SSW2
Gene Alias AA409398; AU041366; Kiaa0077; mKIAA0077; PA200; proteasome (prosome, macropain) activator subunit 4; proteasome activator 200 kDa; proteasome activator complex subunit 4; Proteasome activator PA200; proteasome activator subunit 4; Protein TEMO; Psme4; TEMO
Gene Symbols PSME4
Host Species Rabbit
Immunogen Recombinant protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 103554, 23198, 498433
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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