Invitrogen™ PSME4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA589458

Catalog No. PIPA589458

Description

Immunogen sequence: LYPHQVPLVL QVLKQTARSS SWHARYTVLT YLQTMVFYNL FIFLNNEDAV KDIRWLVISL LEDEQLEVRE MAATTLSGLL QCNFLTMDSP MQIHFEQLCK TKLPKKRKRD PGSVGDTIPS AELVKRHAGV LGLGACVLSS PYDVPTWMPQ LLMNLSAHLN DPQPIEMTVK KTLSNFRRTH HDNWQEHKQQ FTDDQLLVLT DLLVSPCYYA; Positive Samples: MCF-7, U-87MG, 293T, HeLa, Mouse thymus, Mouse brain, Mouse heart, Mouse kidney, Rat liver; Cellular Location: Cytoplasm, Nucleus, Nucleus speckle, cytosol.

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. [UniProt].

Specifications

• Antigen: PSME4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PSME4
• Gene Alias: AA409398; AU041366; Kiaa0077; mKIAA0077; PA200; proteasome (prosome, macropain) activator subunit 4; proteasome activator 200 kDa; proteasome activator complex subunit 4; Proteasome activator PA200; proteasome activator subunit 4; Protein TEMO; Psme4; TEMO
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 103554, 23198, 498433
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1.38 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q14997, Q5SSW2
• Gene Symbols: PSME4
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1634-1843 of human PSME4 (NP_0554292).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG