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Invitrogen™ PST1 Polyclonal Antibody
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Catalog No. PIPA534414
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100 μg
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PIPA534414 100 μg
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Catalog No. PIPA534414 Supplier Invitrogen™ Supplier No. PA534414
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Description

Rabbit Polyclonal Antibody

PA5-34414 can be used with blocking peptide PEP-1456.

Protoplast secreted protein 1 (Pst1) is an anchored plasma membrane protein. Pst1 was previously identified as a protein secreted by yeast regenerating protoplasts, which suggests a role in cell wall construction. Pst1 is a protein with 444 amino acids and is attached to yeast cell wall via a glycosylphosphatidylinisotol (GPI) anchor. Pst1 contains 15 potential N-linked glycosylation sites and is heavily glycosylated. It migrates at approximately 200 kDa on SDS-PAGE when produced in wild type S. cerevisiae. Our Pst1 protein was expressed in a genetically manipulated triple-mutant (TM) S. cerevisiae stain, which results in the production of sole Man8GlcNAc2 carbohydrate structures and Pst1 migration at approximately 100 kDa. When produced in the TM yeast, Pst1 can be recognized by several glycan-specific HIV-1 broadly neutralizing antibodies, including 2G12 and recently identified PGT antibodies. Among several heavily N-glycosylated TM yeast glycoproteins, Pst1 shows higher affinity for 2G12 and efficiently inhibits gp120 interactions with 2G12 and DC-SIGN, and it also blocks 2G12-mediated neutralization of HIV-1 pseudoviruses.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PST1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene PST1
Gene Accession No. A6ZY20
Gene Alias Cell wall mannoprotein PST1; D4214; Haze protective factor 2; HPF2; Protoplast secreted protein 1; PST1; Pst1p; YD9609.09; YDR055W
Gene Symbols PST1
Host Species Rabbit
Immunogen A synthetic peptide from the amino terminus of yeast Pst1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 851625
Target Species Yeast
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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