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Invitrogen™ PSTPIP1 Polyclonal Antibody
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Catalog No. PIPA552712
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100 μL
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PIPA552712 100 μL
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Catalog No. PIPA552712 Supplier Invitrogen™ Supplier No. PA552712
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GMIKRFSGLL HGSPKTTSLA ASAASTETLT PTPERNEGVY TAIAVQEIQG NPASPAQEYR ALYDYTAQNP DELDLSAGDI LEVILEGEDG WWTVERNGQR GFVPGSYLEK Highest antigen sequence identity to the following orthologs: Mouse - 84%, Rat - 80%.

PSTPIP1 is involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PSTPIP1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PSTPIP1
Gene Accession No. O43586
Gene Alias CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; CD2-binding protein 1; CD2BP1; CD2BP1L; CD2BP1S; def-2; H-PIP; PAPAS; PEST phosphatase-interacting protein 1; proline-serine-threonine phosphatase interacting protein 1; proline-serine-threonine phosphatase-interacting protein 1; PSTPIP; Pstpip1; truncated proline-serine-threonine phosphatase interacting protein 1
Gene Symbols PSTPIP1
Host Species Rabbit
Immunogen Recombinant protein fragment of Human PSTPIP1 (Product #RP-90639)
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9051
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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