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Invitrogen™ PSTPIP1 Polyclonal Antibody
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Catalog No. PIPA596793
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100 μL
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PIPA596793 100 μL
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Catalog No. PIPA596793 Supplier Invitrogen™ Supplier No. PA596793
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AFERISANGH QKQVEKSQNK ARQCKDSATE AERVYRQSIA QLEKVRAEWE QEHRTTCEAF QLQEFDRLTI LRNALWVHSN QLSMQCVKDD ELYEEVRLTL EGCSIDADID SFIQAKSTGT EPPAPVPYQN YYDREVTPLT SSPGIQPSCG MIKRFSGLLH GSPKTTSLAA SAASTETLTP TPERNEGVYT AIAVQEIQGN PASPAQEYRA LYDYTAQNPD ELDLSAGDIL EVILEGEDGW WTVERNGQRG FVPGSYLEKL; Positive Samples: THP-1, mouse spleen, mouse thymus, mouse brain, rat brain, Mouse spleen, Mouse thymus, Mouse brain, Rat brain; Cellular Location: Cell projection, Cleavage furrow, Cytoplasm, cytoskeleton, lamellipodium, perinuclear region, uropodium.

PSTPIP1 is involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PSTPIP1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.46 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene PSTPIP1
Gene Accession No. O43586, P97814
Gene Alias CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; CD2-binding protein 1; CD2BP1; CD2BP1L; CD2BP1S; def-2; H-PIP; PAPAS; PEST phosphatase-interacting protein 1; proline-serine-threonine phosphatase interacting protein 1; proline-serine-threonine phosphatase-interacting protein 1; PSTPIP; Pstpip1; truncated proline-serine-threonine phosphatase interacting protein 1
Gene Symbols PSTPIP1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 157-416 of human PSTPIP1 (NP_0039692).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19200, 300732, 9051
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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