Invitrogen™ PSTPIP1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596793

Catalog No. PIPA596793

Description

Immunogen sequence: AFERISANGH QKQVEKSQNK ARQCKDSATE AERVYRQSIA QLEKVRAEWE QEHRTTCEAF QLQEFDRLTI LRNALWVHSN QLSMQCVKDD ELYEEVRLTL EGCSIDADID SFIQAKSTGT EPPAPVPYQN YYDREVTPLT SSPGIQPSCG MIKRFSGLLH GSPKTTSLAA SAASTETLTP TPERNEGVYT AIAVQEIQGN PASPAQEYRA LYDYTAQNPD ELDLSAGDIL EVILEGEDGW WTVERNGQRG FVPGSYLEKL; Positive Samples: THP-1, mouse spleen, mouse thymus, mouse brain, rat brain, Mouse spleen, Mouse thymus, Mouse brain, Rat brain; Cellular Location: Cell projection, Cleavage furrow, Cytoplasm, cytoskeleton, lamellipodium, perinuclear region, uropodium.

PSTPIP1 is involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.

Specifications

• Antigen: PSTPIP1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PSTPIP1
• Gene Alias: CD2 antigen-binding protein 1; CD2 cytoplasmic tail-binding protein; CD2-binding protein 1; CD2BP1; CD2BP1L; CD2BP1S; def-2; H-PIP; PAPAS; PEST phosphatase-interacting protein 1; proline-serine-threonine phosphatase interacting protein 1; proline-serine-threonine phosphatase-interacting protein 1; PSTPIP; Pstpip1; truncated proline-serine-threonine phosphatase interacting protein 1
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19200, 300732, 9051
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.46 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O43586, P97814
• Gene Symbols: PSTPIP1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 157-416 of human PSTPIP1 (NP_0039692).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov